Lupus nephritis: when lupus affects the kidneys
Dr. Joan J. Morales Lappot, MD3 min read · Leer en español
In briefLupus is an autoimmune disease that can affect the skin, joints, blood and more. In up to about half of adults with lupus, it eventually reaches the kidneys. This is called lupus nephritis.
Who is at higher risk
Lupus nephritis is more common, and often more severe, in Black, Hispanic and Asian patients, and it often appears within the first years after lupus is diagnosed. That is why regular urine tests are part of lupus care, even when you feel well.
Warning signs
- Foamy urine or protein on a urine test
- Blood in the urine
- Swelling in the legs or around the eyes
- New or rising high blood pressure
- A rising creatinine
- You notice foamy or dark urine
- You have new swelling or a big weight gain
- You have fever while taking immune medicines
Diagnosis and treatment
A kidney biopsy shows the type and how active the inflammation is, which guides treatment. Many patients do well with a combination of immune medicines, hydroxychloroquine, blood pressure control and medicines that reduce protein. Newer treatments have improved results in recent years. I work closely with your rheumatologist so both teams follow the same plan.